What is Tadalafil ?
Tadalafil (Generic Cialis) is a PDE-5 inhibitor used to treat conditions of moderate to severe erectile dysfunction (ED). Studies have shown that generic Cialis to be a well-tolerated and effective option in Korean men suffering from a broad spectrum of severity and aetiology. It improved erectile function, with intercourse attempts successfully.
Key features and distinguishing points
- Effects last up to 36 hours
- Can be taken with or without food, along with high-fat meals
- Is well-tolerated
- Visual side effects are considerably lower than other PDE-5 inhibitors like Sildenafil.
How It Works
Tadalafil is a selective inhibitor for cyclic guanosine monophosphate that prevents the degradation of cGMP molecules.
cGMP is synthesised in response to nitric oxide release during sexual stimulation. Increased levels of cGMP result in the relaxation of smooth muscles in the corpus cavernosum with increased blood flow to penile regions, giving rise to a hard and long-lasting erection during sexual activity.
Research has shown that it has a different structure than PDE-5 inhibitors like Sildenafil 100 mg ( Cenforce 100mg )and Vardenafil that impact its pharmacodynamics and safety.
It is 9000 times more selective for PDE-5 enzymes that enables it a safer pharmacological profile and suited for patients experiencing increased side-effects with other PDE-5 inhibitors like Sildenafil.
The increased selectivity decreases the risk of side effects involving other organs, especially visual disturbances and cardiovascular symptoms.
When and How to Take Tadalafil 20mg
Because of its higher strength, it is the physician who will have the final say in determining when to take Tadalafil 40 based on
- Your severity of ED symptoms
- Tolerability to higher Tadalafil strengths
- Concomitant use of any medication that you have been using previously, along with Tadalafil 40
The best way to take 40 mg Tadalafil is with a glass of water an hour or two before sexual activity. It can be taken with or without meals, as food does not impact its absorption or pharmacodynamics.
Tadalafil 40 is a higher strength derivative because of which it should not be used daily and only during periods of sexual activity.
Important usage guidelines
- Do not use alcohol along with Tadalafil 20 mg or 40mg, as it can give rise to side effects and impact its efficacy.
- Do not drive or operate heavy machinery after using it
- You will need to be sexually stimulated for the effects to start kicking in
Benefits of Tadalafil 20 mg
- Lasts for a much longer time
- Effective in moderate to severe Ed cases
- Allows multiple erections during the effective period
- Improves relationship satisfaction
Side Effects and Precautions
Studies have shown back pain and myalgia to be two common side effects associated with Tadalafil use because of its effects on smooth muscle tissues. Additionally, the vasodilatory effect of the medication can give rise to symptoms of headache and dyspepsia, with an incidence of 15.8% and 8.2%, respectively.
As such, It use is not associated with thrombocytopenia, neutropenia, or hepatotoxicity.
Serious side-effects with Tadalafil use are rare with approximately 1 in 1000 people using them. These effects are observed in the form of eye pain, blurred vision, dizziness and difficulty breathing.
Drug Interactions and Contraindications
Medications to avoid
- It should not be used alongside nitrates ( the ones used to treat chest pain or angina ).
- It should be avoided with alpha-blockers as it can result in sudden blood pressure fluctuations.
- Keeping in mind its higher strength, 40mg tadalafil should not be used concomitantly with other PDE-5 inhibitors as it can result in overdosing symptoms.
Conditions where caution is needed
- It should be used with caution in conditions predisposing to priapism, like leukemia or sickle-cell anemia.
- Avoid using It if you have recently had a stroke, a heart attack, or been diagnosed with a serious liver anomaly.
- Inform your physician if you experience a prolonged or painful erection for more than 4-6 hours, and get urgent medical help.
- Contact your healthcare provider if you observe sudden loss of hearing or vision anomalies in one or both eyes.
Frequently Asked Questions (FAQs)
What is the difference between Tadalafil and Viagra
The most important difference between Tadalafil and Viagra is in their primary ingredient, which impacts their effectiveness and overall efficiency. It contains Tadalafil as its active ingredient and has a longer-lasting duration. Viagra lasts for a shorter period and has a reduced effect with high-fat meals.
Is there a difference between this and the imported versions?
As long as the medications contain real Tadalafil and are approved by a trusted regulatory body, the effect remains the same irrespective of their area of manufacturing. Irrespective of the version, It has a Controlled Status and requires a prescription from a registered practitioner to be procured or ordered online.
What should I know when buying it in Korea?
Tadalafil is a prescription-only medication in Korea and you need to visit a urologist or general physician for a diagnosis and prescription for the medicine. You can either avail from pharmacies dealing with ED medications or order it online that will deliver the medication at your place safely. Choose a reputed online platform with independent reviews to ensure genuine medication and effective delivery.
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